Published: September 2017 in Fertility and Sterility
Authors: Cobo A, Coello A, Remohí J, Serrano J, de Los Santos JM, Meseguer M
Institution: Instituto Valenciano de Infertilidad Valencia
This study examined 3,794 embryos created from frozen eggs in 631 cycles, and 9,935 embryos created from fresh eggs in 1,359 cycles, over a period of two years. All the eggs frozen were done so using modern technology (vitrification), which means the results are applicable to eggs frozen today. While embryos created from frozen eggs took, on average, an additional hour to divide and develop, that delay did not have an effect on the quality of the embryos: the percentage of high-grade embryos and low-grade embryos was the same for frozen eggs as it was for fresh. The implantation rate, defined as the number of gestational sacs (early-stage placentas) detected on an ultrasound, was essentially unchanged between the frozen-egg group and the fresh-egg group. And importantly, there was no statistically significant difference between the live birth rates, based on the journey of the egg.
Published: October 26, 2017 in the New England Journal of Medicine
Authors: Jacques Donnez, M.D., Ph.D., & Marie‑Madeleine Dolmans, M.D., Ph.D.
Institution: Société de Recherche pour l’Infertilité
This review of the current research into fertility preservation options for women with cancer, women with other health conditions, and women who want to preserve their fertility for personal reasons concludes that oocyte vitrification (egg freezing) is the “best strategy” for women facing age-related infertility, “yielding a cumulative live-birth rate of 60.5% among healthy women” who freeze before they’re 35.
Published: June 30, 2010 in Human Reproduction, Vol. 25, No. 9
Authors: Ana Cobo, Marcos Meseguer, José Remohí, Antonio Pellicer
Institution: Instituto Valenciano de Infertilidad (IVI), University of Valencia, Valencia, Spain
This randomized controlled trial of over 600 egg recipients (women undergoing IVF with an egg from a donor) was designed to compare the outcome of vitrified-banked (frozen and thawed) eggs with the “gold standard” procedure of using fresh eggs. The result: ongoing pregnancy rates were roughly similar between the group using frozen eggs and the group using fresh, confirming the “non-inferiority” of frozen eggs.