January 29, 2016 | The Real Deal
Kristen Mancinelli, MSPH, Director of Partnerships and Education
First, let’s acknowledge my clever pun. The age of the egg! Her time has come! We’ve entered a new era!
Okay. On to more serious business. The reason I’ve been thinking about the age of the egg is because, according to doctors, the age of the eggs a woman freezes is so important to her chances for pregnancy later on. Why? What’s so different about older eggs?
First, you probably know that a woman is born with all the eggs she’ll ever have, which is why the quantity of eggs declines over time (you lose one or more every month). That diminishing pool of eggs feels very worrying—you may even think that’s the biggest barrier to you eventually getting pregnant, if you want to.
And you’re right to be concerned: the number of eggs is important. But there’s something else that changes over time. An egg is a type of cell, and like all living things, cells age. As eggs age, their DNA ages, too. Eventually, they develop what are called “chromosomal defects,” or problematic changes to the genetic material that tells the cell how to function. Older eggs are likely to have more defects than younger ones, and therefore have a harder time doing what they’re supposed to do (make a baby).
Why all this damage to the eggs? I mean, I eat organic food and go to the gym. I don’t smoke. I’m in good health! Why should I be worried about the health of my eggs?
The fact of the matter is that cells are very fragile, and the human body is not always the safest place. The cells in your body endure fevers, infections, stress, hangovers, and all manner of molecular unpleasantness (like free radicals) that cause them harm. Medications and environmental toxins can also cause damage—this is precisely why women facing some cancer treatments are encouraged to freeze their eggs first. The longer your eggs—or any living things—hang around, the more that time has its way with them.
Most of the cells in your body “regenerate,” or get cleared out and replaced by younger, healthier ones. Sometimes we can see the regeneration happening, like with skin cells—it’s the reason your tan fades a week after your Cabo vacation. But the same thing happens deep inside your body. Red blood cells, for instance, get recycled every 3–4 months, and liver cells get replaced once every year or so. Anyone who’s ever broken a bone can tell you that even the cells in the human skeleton grow anew. You may be in your 20s, 30s, or 40s, but most of the physical stuff that makes up you is less than a decade old.
The one exception, of course, is your eggs. Those went with you to pre-school and they’ve been enduring the elements, so to speak, ever since.
So not only do you have fewer eggs as you get older—the ones you do have are more likely to have those pesky defects. That’s why the guidelines for how many eggs a woman should freeze are based on… ready for it? Yeah. Your age at the time of freezing.
It doesn’t matter if you look 22. Your eggs know how old you really are. Younger eggs are simply healthier than older ones, and healthier eggs lead more often to pregnancy.
We know we can’t make more eggs, and we can’t make old eggs young again. But we can freeze eggs in time. And this matters—a lot. According to the American Society for Reproductive Medicine, birth rates for women undergoing IVF declined about 10% every two years for women between the ages of 35 and 44, when they used their own eggs of the same age. In contrast, the birth rate was the same for all women, regardless of age, when they used young, donor eggs.
Like I said—it’s the age of the egg!
Questions? Tweet us @extendfertility.